Antiphosphotyrosine Recovery of Phospholipase C Activity After EGF Treatment of A-431 Cells
Authors:
- 19 August 1988
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 241 (4868) , 968-970
Abstract
A tenfold increase in phospholipase C activity specific for phosphatidylinositol 4,5-bisphosphate (PIP 2 ) was immunopurified from extracts of A-431 epidermoid carcinoma cells stimulated with epidermal growth factor. This finding suggests a biochemical link between growth factor-stimulated tyrosine kinase activity and PIP 2 hydrolysis.Keywords
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