PhysiologicIgGBiodistribution, Transport, and Clearance: Implications for Monoclonal Antibody Products
Authors:
- Jennifer L. RojkoJRJennifer L. Rojko
- Shari Price‐SchiaviSPShari Price‐Schiavi
- 15 March 2010
- book chapter
- Published by Wiley
- p. 1-36
Abstract
Following administration, monoclonal antibodies become part of the endogenous IgG pool for distribution, transport, and clearance unless these physiologic processes are altered by antibody CDR‐epitope interactions. This article aims to provide helpful information regarding potential monoclonal antibody IgG test article (non‐CDR‐mediated) binding to specific tissues, cell types or other tissue elements, and subcellular locations following exogenous intravenous administration in animal model test systems.Keywords
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