The neuroscience and context of adolescent depression

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Abstract
Adolescent depression is a growing public health concern with an increased risk of negative health outcomes, including suicide. The use of antidepressants and psychotherapy has not halted its increasing prevalence, and there is a critical need for effective prevention and treatment. We reviewed the neuroscience of adolescent depression, with a focus on the neurocircuitry of sustained threat and summarised contextual factors that have an impact on brain development and the pathophysiology of depression. We also reviewed novel treatment models.Conclusion: Attention to the relevant neurocircuitry and contextual factors implicated in adolescent depression is necessary to advance prevention and treatment development.
Funding Information
  • Vetenskapsrådet (350‐2012‐303)
  • Brain and Behavior Research Foundation
  • National Institute of Mental Health (7R01MH085734, R01MH085734‐02S1, R01MH085734‐05S1, K01MH097978)
  • American Foundation for Suicide Prevention (PDF‐1‐064‐13)

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