Assessment of the Efficacy of Tributylammonium Alginate Surface-Modified Polyurethane as an Antibacterial Elastomeric Wound Dressing for both Noninfected and Infected Full-Thickness Wounds

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Abstract
Risk factors of non-healing wounds include persistent bacterial infections and rapid onset of dehydration; therefore, wound dressings should be used to accelerate the healing process by helping to disinfect the wound bed and provide moisture. Herein, we introduce a transparent tributylammonium alginate (TBAH-Alg) surface-modified cationic polyurethane (CPU) wound dressing, which is appropriate for full-thickness wounds. We studied the physicochemical properties of the dressing using FTIR, 1H NMR, 13C NMR spectroscopy, and SEM, EDX and thermo-mechanical analyses. The surface-modified polyurethane demonstrated improved hydrophilicity and tensile Young’s modulus that approximated natural skin, and was in the range of 1.5–3 MPa. Cell viability and in vitro wound closure, assessed by MTS and the scratch assay, confirmed that the dressing was cytocompatible and possessed fibroblast migratory-promoting activity. The surface modified CPU had up to 100% antibacterial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), as gram positive and gram negative bacteria, respectively. In vivo assessments of both non-infected and infected wounds revealed that the surface-modified CPU dressing resulted in a faster healing rate since it reduced the persistent inflammatory phase, enhanced collagen deposition, and improved the formation of mature blood vessels when compared with CPU and commercial Tegaderm™ wound dressing.
Funding Information
  • Royan Institute
  • Semnan University

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