Mutation in the Gene Responsible for Cystic Fibrosis and Predisposition to Chronic Rhinosinusitis in the General Population
Authors:
- Birgitta MoylanBMBirgitta Moylan
- Donald A. LeopoldDLDonald A. Leopold
- Jean KimJKJean Kim
- Ronald C. RubensteinRRRonald C. Rubenstein
- Alkis TogiasATAlkis Togias
- David ProudDPDavid Proud
- Pamela L. ZeitlinPZPamela L. Zeitlin
- Garry R. CuttingGCGarry R. Cutting
Open Access
- 11 October 2000
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 284 (14) , 1814-1819
Abstract
Inflammation of the sinus epithelium is a common consequence of upper respiratory infections.1 The persistent form of this condition, chronic rhinosinusitis (CRS), is a prevalent chronic disease affecting about 14% of the US population and accounting for 11.6 million office visits in 1991.2,3 Many factors have been reported to contribute to the pathology of rhinosinusitis, but little is known of the molecular basis of this condition.2,4 A greater understanding of the cause and pathophysiology of sinus disease at the molecular level may provide new avenues for diagnosis and therapy development.Keywords
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