COMPARATIVE STUDY OF THE CLINICAL EFFECT OF ACENOCOUMAROL (SINTROM®) AND PHENPROCOUMON (MARCOUMAR®) IN MYOCARDIAL INFARCTION AND ANGINA PECTORIS

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Abstract
A controlled clinical trial was performed in more than 250 patients with myocardial infarction or angina pectoris to determine whether any difference in clinical effect could be observed between acenocoumarol (Sintrom®) and phenprocoumon (Marcoumar®). The average observation period was almost three years. For the myocardial infarction group (both with and without relative contraindications) there proved to be a small but significant difference in the stability of the hypocoagulability of these two coumarin preparations: phenprocoumon gave the most stable results. Judging from the mortality, morbidity, and the number and severity of the bleeding complications, however, there was no statistically significant difference between the groups treated with these two anticoagulants. The favourable results obtained in this study with the short‐acting acenocoumarol are based on the strict supervision of patients on prolonged anticoagulant treatment provided by the Netherlands Thrombosis Service, in which the control by nurses plays an important role.