Tandem Catalysis: Access to Ketones from Aldehydes and Arylboronic Acids via Rhodium‐Catalyzed Addition/Oxidation
- 7 May 2007
- journal article
- research article
- Published by Wiley in Advanced Synthesis & Catalysis
- Vol. 349 (7) , 1180-1184
Abstract
Direct cross‐coupling reactions of aromatic aldehydes with arylboronic acids afforded ketones in high yields and under mild conditions in the presence of a rhodium catalyst, acetone and a base. This new reaction, involving a formal aldehyde CH bond activation, is believed to proceed via a tandem process involving addition of the organometallic species to the aldehyde followed by oxidation by β‐hydride transfer.Keywords
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