The CDC20-APC/SOX2 signaling axis: An achilles' heel for glioblastoma
Open Access
- 8 April 2016
- journal article
- opinion
- Published by Taylor & Francis in Molecular & Cellular Oncology
- Vol. 3 (3) , e1075644
Abstract
Glioblastoma stem-like cells (GSCs) play a critical role in glioblastoma progression and recurrence. We discuss recent results on the role of the mitotic ubiquitin ligase cell division cycle 20–anaphase-promoting complex (CDC20-APC) in the governance of cardinal GSC functions through a mechanism involving the transcription factor sex-determining region Y-box 2 (SOX2). These findings expand the non-mitotic roles of CDC20-APC with implications for stem cell biology.Keywords
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