Ropinirole Prolonged Release

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Abstract
▴ Ropinirole prolonged release is a non-ergoline dopamine receptor agonist that is indicated for the treatment of Parkinson’s disease. ▴ Once-daily ropinirole prolonged release and threetimes-daily ropinirole immediate release have similar exposure over 24 hours. The prolonged-release formulation is associated with fewer fluctuations in plasma ropinirole concentrations. ▴ Two well designed, placebo- or active comparatorcontrolled trials examined the efficacy of ropinirole prolonged release in patients with advanced Parkinson’s disease suboptimally controlled by levodopa. In the placebo-controlled trial, 24 weeks’ therapy with ropinirole prolonged release 6–24 mg once daily reduced hours of ‘off’ time (primary endpoint) to a significantly greater extent than placebo. In the active comparator-controlled trial, significantly more ropinirole prolonged-release recipients than ropinirole immediate-release recipients maintained a ≥20% reduction from baseline in ‘off’ time at week 24 (primary endpoint). ▴ Ropinirole prolonged release 6–24 mg once daily was generally well tolerated in patients with advanced Parkinson’s disease; adverse events were generally typical of non-ergoline dopamine receptor agonists.

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