Chronic granulomatous disease: A multicenter study from the MENA region
Authors:
- Salem Al-TamemiSalem Al-Tamemi
- Najla MekkiNMNajla Mekki
- Fatima AilalFatima Ailal
- Raed AlzyoudRaed Alzyoud
- Waleed Al-HerzWaleed Al-Herz
- Maryam Al-NesfMaryam Al-Nesf
- Nesrine RadwanNesrine Radwan
- Iman NasrINIman Nasr
- Musab Al JabriMJMusab Al Jabri
- Thouraya KammounTKThouraya Kammoun
- Assma DablyADAssma Dably
- Motasem AlsuweitiMAMotasem Alsuweiti
Open Access
- 7 July 2026
- journal article
- Published by Rockefeller University Press in Journal of Human Immunity
- Vol. 2 (5) , e20260014
Abstract
Al-Tamemi et al. describe that autosomal recessive CGD represents a significant disease in the MENA region associated with significant morbidity and mortality. Regional challenges are related to universal newborn BCG vaccine, lack of newborn screening programs, and limitation of curative interventions such as hematopoietic stem cell transplantation and gene therapy.Keywords
This publication has 67 references indexed in Scilit:
- Interferon Gamma for Chronic Granulomatous DiseaseNew England Journal of Medicine, 1991
- Trimethoprim-Sulfamethoxazole Prophylaxis in the Management of Chronic Granulomatous DiseaseThe Journal of Infectious Diseases, 1990
- Molecular genetics of chronic granulomatous disease.1988
- BCG dissemination in chronic granulomatous disease (CGD).1986
- The respiratory burst of phagocytosis: Biochemistry and subcellular localizationImmunology Letters, 1985
- Treatment of seven cases of chronic granulomatous disease with sulfamethoxazole-trimethoprim (SMX-TMP)European Journal of Pediatrics, 1978
- Thoracic wall invasion secondary to pulmonary aspergillosis: a complication of chronic granulomatous disease of childhoodAmerican Journal of Roentgenology, 1977
- PSEUDOMONAS CEPACIA PNEUMONIA IN A CHILD WITH CHRONIC GRANULOMATOUS DISEASE AND SELECTIVE IgA DEFICIENCYActa Paediatrica, 1976
- The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes.Journal of Clinical Investigation, 1975
- NADPH oxidase deficiency in X-linked chronic granulomatous disease.Journal of Clinical Investigation, 1975