Quantitative Thin Layer Chromatographic Multi-Sulfonamide Screening Procedure: Collaborative Study

Authors:
  • COCollaborators
    Collaborators
  • LGL Gonzales
    L Gonzales
  • THT Hunter
    T Hunter
  • CKC Kao
    C Kao
  • MLM Leadbetter
    M Leadbetter
  • FMF Mitchell
    F Mitchell
  • JPJ Patterson
    J Patterson
  • KSK E Soroka
    K E Soroka
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Abstract
A thin layer chromatographic procedure suitable for detection of multiple sulfonamides at 0.1 ppm was studied in an interlaboratory collaborative study. Sulfamethazine, sulfadimethoxine, and sulfaquinoxaline were variously analyzed in liver and muscle tissues from swine, turkey, and duck. The average recovery for all drugs across all tissues was 95%. The corresponding repeatability and reproducibility were 7.7% and 10.5%, respectively.