V3 Region Polymorphisms in HIV-1 from Brazil: Prevalence of Subtype B Strains Divergent from North American/European Prototype and Detection of Subtype F
Authors:
- Ester C. SabinoESEster C. Sabino
- Eugene G. ShpaerESEugene G. Shpaer
- Vera BongertzVBVera Bongertz
- Luis BrigidoLBLuis Brigido
- Mark D. C. GuimaraesMGMark D. C. Guimaraes
- Euclides A. CastilhoECEuclides A. Castilho
- Bernardo Galvão-CastroBGBernardo Galvão-Castro
- James I. MullinsJMJames I. Mullins
- R. Michael HendryRHR. Michael Hendry
- Allen MayerAMAllen Mayer
- 1 May 1994
- journal article
- research article
- Published by SAGE Publications in AIDS Research and Human Retroviruses
- Vol. 10 (5) , 569-576
Abstract
Viral DNA sequences were determined over the V3 region of env from 28 infected individuals living in the high HIV-1 prevalence Brazilian cities of Rio de Janeiro and São Paulo. Twenty-six belonged to envelope sequence subtype B, prevalent in North America and Europe, and one was classified as subtype F, found recently in Brazil and in Romania (one appeared to be a B/F recombinant). Octameric sequences at the tip of the subtype B V3 loops were variable and distinct from those prevalent in North America and Europe. The GPGR motif, prevalent in North American/European strains, was found in only 8 (28.5%) sequences, whereas GWGR was found in 12 (43%) and novel sequences in 8 (28.5%). Brazilian subtype B sequences also diverged from the consensus North American/European strains over the remainder of the V3loop. These results suggest that Brazilian HIV-1 B strains may have important antigenic differences from prototype subtype B strains currently being evaluated for use in HIV vaccines. These results should be taken into account for future vaccine programs in Brazil.Keywords
This publication has 29 references indexed in Scilit:
- An Individual with a High Prevalence of a Tat -Defective Provirus in Peripheral BloodAIDS Research and Human Retroviruses, 1993
- Genetic heterogeneity of the V3 region of the HIV-1 envelope glycoprotein in BrazilAIDS, 1993
- HIV-1 strains from India are highly divergent from prototypic African and US/European strains, but are linked to a South African isolateAIDS, 1993
- Genotypic and Phenotypic Variation of HIV-1: Impact on AIDS Pathogenesis and Vaccination (Part 1 of 2)1993
- Induction of Broadly Cross-Reactive Cytotoxic T Cells Recognizing an HIV-1 Envelope DeterminantScience, 1992
- Characteristics of the Principal Neutralizing Determinant of HIV-1 Prevalent in JapanAIDS Research and Human Retroviruses, 1991
- Identification of the Envelope V3 Loop as the Primary Determinant of Cell Tropism in HIV-1Science, 1991
- Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp!20 geneNature, 1991
- Multiple aligned sequence editor (MASE)Trends in Biochemical Sciences, 1988
- REPLICATIVE CAPACITY OF HUMAN IMMUNODEFICIENCY VIRUS FROM PATIENTS WITH VARYING SEVERITY OF HIV INFECTIONThe Lancet, 1986