Automated generation of gene-edited CAR T cells at clinical scale
Authors:
Open Access
- 1 March 2021
- journal article
- research article
- Published by Elsevier in Molecular Therapy - Methods & Clinical Development
- Vol. 20, 379-388
Abstract
No abstract availableKeywords
This publication has 35 references indexed in Scilit:
- Endogenous TCR promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated TCR knockout CARBlood, 2020
- Straightforward Generation of Ultrapure Off-the-Shelf Allogeneic CAR-T CellsFrontiers in Bioengineering and Biotechnology, 2020
- CRISPResso2 provides accurate and rapid genome editing sequence analysisNature Biotechnology, 2019
- Chimeric Antigen Receptor T-Cells (CAR T-Cells) for Cancer Immunotherapy – Moving Target for Industry?Pharmaceutical Research, 2018
- Integration of a CD19 CAR into the TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T CellsMolecular Therapy, 2017
- Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejectionNature, 2017
- Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cellsScience Translational Medicine, 2017
- CHOPCHOP v2: a web tool for the next generation of CRISPR genome engineeringNucleic Acids Research, 2016
- COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target SitesMolecular Therapy Nucleic Acids, 2014
- An online bioinformatics tool predicts zinc finger and TALE nuclease off-target cleavageNucleic Acids Research, 2013