Molecular Genetic Characterisation of Frontotemporal Dementia on Chromosome 3
Authors:
- Sarah LloydSLSarah Lloyd
- Jeremy BrownJBJeremy Brown
- Susanne GydesenSGSusanne Gydesen
- S. Asger SorensenSSS. Asger Sorensen
- Arne BrunABArne Brun
- Elisabet EnglundEEElisabet Englund
- Christine HumphreysCHChristine Humphreys
- David HousmanDHDavid Housman
- Mary BaduraMBMary Badura
- Vincent Stanton Jr.VJVincent Stanton Jr.
- Kay TaylorKTKay Taylor
- 1 July 1999
- journal article
- Published by S. Karger AG in Dementia and Geriatric Cognitive Disorders
- Vol. 10 (Suppl. 1) , 93-101
Abstract
We have previously localized a locus causing familial nonspecific dementia to the centromeric region of chromosome 3 in a pedigree from the Jutland area of Denmark. This pedigree shows anticipation. Here we present further analysis of these anticipation data which are suggestive of trinucleotide repeat expansion involvement. We also outline our strategies to clone the mutant gene via its putative associated trinucleotide repeat sequence.Keywords
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