Monte Carlo simulations to evaluate geometric variations of a new Iodine-125 seed

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Abstract
The Nuclear and Energy Research Institute and the National Nuclear Energy Commission (IPEN-CNEN/SP) are developing a new Iodine-125 seed for use in brachytherapy. The manufacturing process includes cutting the titanium tube, welding the ends, and performing leak tests. Seed approval is based on a microscopic analysis of its external geometry. The dosimetric methodology follows Task Group 43 (TG-43), which adopts the Monte Carlo method as the standard simulation technique. However, TG-43 does not account for geometric variations that may occur during the manufacturing process. This study investigated two types of variation: (1) the seed width after welding, and (2) the random positions that the core may assume within the seed. A total of 100 simulations were performed for each variation. The width was measured experimentally using a caliper, after welding, while the core position was modeled using a random number generator, since it is not feasible to measure it directly. These values were used to generate 201 input files for simulations in MCNP 6.2: 100 for each investigated parameter and one for the reference geometry (IPEN-CNEN/SP seed). The results were analyzed using MATLAB through bidimensional matrices of 101 × 101 points. For each point in the matrix, the mean, standard deviation, relative difference (compared to the reference geometry), and Type A uncertainty were calculated. The main results were: a standard deviation of 0.6% and a relative difference of 11% for the seed width; and a standard deviation of 50% and a relative difference of 25% for the core position. The Type A uncertainty was below 0.3% in all cases.
Funding Information
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (406761/2022-1)
  • IPEN/CNEN (2020.06, 37)
  • Centros de Pesquisa, Inovação e Difusão, Fundação Amazônia Paraense de Amparo à Pesquisa (50332-0 and 2020/07065-4.)

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