Physical Dependence of Opiate-Like Peptides
Authors:
- Eddie WeiEWEddie Wei
- Horace LohHLHorace Loh
- 24 September 1976
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 193 (4259) , 1262-1263
Abstract
Methionine-enkephalin and β-endorphin, endogenous peptides with activities similar to those of opiates, were infused for 70 hours into the periaqueductal gray-fourth ventricular spaces of the rat brain. When challenged with a naloxone, a specific opiate antagonist, these animals manifested a typical morphine-like withdrawal syndrome. These results show that such peptides can cause physical dependence.Keywords
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