Genome editing–induced t(4;11) chromosomal translocations model B cell precursor acute lymphoblastic leukemias with KMT2A-AFF1 fusion
Open Access
- 2 January 2024
- journal article
- letter
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 134 (1)
Abstract
A t(4;11) leukemia model established from CRISPR-engineered chromosomal translocations between the KMT2A and AFF1 genes recapitulate proteomic, epigenomic, and transcriptomic features of primary patient leukemias.Keywords
Funding Information
- National Institutes of Health (CA214888)
- Stanford Maternal and Child Health Research Institute (n/a)
- Alex’s Lemonade Stand Foundation (young investigator award)
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