(±) Gancochlearols A and B: cytotoxic and COX-2 inhibitory meroterpenoids from Ganoderma cochlear
- 5 December 2018
- journal article
- research article
- Published by Taylor & Francis in Natural Product Research
- Vol. 34 (16) , 2269-2275
Abstract
(+)- and (−)-gancochlearols A (1) and B (2), two pairs of dimeric mertoterpenoid enantiomers were isolated from the fruiting bodies of Ganoderma cochlear. Their structures were identified by spectroscopic methods. Biological assessments show that the enantiomers of 1 and 2 are cytotoxic against three human cancer cell lines (A549, K562, Huh-7) and could inhibit COX-2 expression with IC50 values less than 10 μM.Keywords
Funding Information
- National Key Research and Development Program of China (2017YFA0503900)
- National Science Fund for Distinguished Young Scholars (81525026)
- National Natural Science Foundation of China (21472199)
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