Evidence for a Vesicular Transport Mechanism in Hepatocytes for Biliary Secretion of Immunoglobulin A
Authors:
- 13 June 1980
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 208 (4449) , 1276-1278
Abstract
Quantitative electron microscopic autoradiography and diaminobenzidine cytochemistry provide evidence for an uptake and vesicular transport mechanism for iodine-125-labeled immunoglobulin A from plasma to bile by hepatocytes in vivo. The data confirm the existence of a hepatobiliary pathway for secretion of immunoglobulin A into the intestine and are consistent with a vesicular transport mechanism for biliary proteins within liver parenchymal cells.Keywords
This publication has 12 references indexed in Scilit:
- Bile Secretory Apparatus: Evidence for a Vesicular Transport Mechanism for Proteins in the Rat, Using Horseradish Peroxidase and [125I]InsulinGastroenterology, 1980
- Endocytic vesicles in liver carry polymeric IgA from serum to bileBiochimica et Biophysica Acta (BBA) - General Subjects, 1979
- Entry of Insulin Into Human Cultured Lymphocytes: Electron Microscope Autoradiographic AnalysisScience, 1978
- Sources of the proteins of rat bileBiochimica et Biophysica Acta (BBA) - General Subjects, 1978
- Relationships Between Immunoglobulins and the Intestinal EpitheliumGastroenterology, 1978
- High levels of secretory IgA and free secretory component in the serum of rats with bile duct obstruction.Journal of Experimental Medicine, 1978
- Rat bile as a convenient source of secretory IgA and free secretory componentEuropean Journal of Immunology, 1977
- Mucosal and Glandular Distribution of Immunoglobulin Components: Differential Localization of Free and Bound SC in Secretory Epithelial CellsThe Journal of Immunology, 1974
- LOCALIZATION OF FREE AND BOUND SECRETORY COMPONENT IN HUMAN INTESTINAL EPITHELIAL CELLSJournal of Experimental Medicine, 1974
- Secretory Immunoglobulins1968