Palladium‐Catalyzed Insertion of an Allene into an Aminal: Aminomethylamination of Allenes by C-N Bond Activation
Authors:
- 30 May 2014
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 53 (28) , 7272-7276
Abstract
A new and atom‐economic palladium‐catalyzed aminomethylamination of allenes with aminals by CN bond activation is described. This direct and operationally simple method provides a fundamentally novel approach for the synthesis of 1,3‐diamines. Mechanistic studies suggest that a unique cationic π‐allylpalladium complex containing an aminomethyl moiety is generated as a key intermediate through the carbopalladation of the allene with a cyclometalated palladium–alkyl species.Keywords
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