Effect of high intratesticular estrogen on global gene expression and testicular cell number in rats
Open Access
- 1 January 2010
- journal article
- Published by Springer Nature in Reproductive Biology and Endocrinology
- Vol. 8 (1) , 72
Abstract
The identification of estrogen receptors alpha and beta and aromatase in the testis has highlighted the important role of estrogens in regulating spermatogenesis. There is a wealth of information on the deleterious effects of fetal and neonatal exposure of estrogens and xenoestrogens in the testis, including spermiation failure and germ cell apoptosis. However, very little is known about gene transcripts affected by exogenous estradiol exposure in the testis. The objective of the present study was to unveil global gene expression profiles and testicular cell number changes in rats after estradiol treatment.Keywords
This publication has 63 references indexed in Scilit:
- Estrogen effects on fetal and neonatal testicular developmentReproduction, 2006
- Estrogen and Spermatogenesis*Endocrine Reviews, 2001
- Cancer Risk in Men Exposed In Utero to DiethylstilbestrolJNCI: Journal of the National Cancer Institute, 2001
- Morphologic Changes in Efferent Ductules and Epididymis in Estrogen Receptor‐α Knockout MiceJournal of Andrology, 2000
- Impairment of spermatogenesis in mice lacking a functional aromatase (cyp 19) geneProceedings of the National Academy of Sciences, 1999
- Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?Endocrine Reviews, 1999
- Generation and reproductive phenotypes of mice lacking estrogen receptor βProceedings of the National Academy of Sciences, 1998
- A role for oestrogens in the male reproductive systemNature, 1997
- Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility.Endocrinology, 1996
- Diethylstilbestrol exposure in utero: review of literature.1984