Training Enhances ANP Lipid-Mobilizing Action in Adipose Tissue of Overweight Men

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Abstract
T subjects. Methods: Ten overweight men aged 26.0 ± 1.4 yr with a mean body mass index of 27.6 ± 0.2 kg·m−2, performed aerobic exercise 5 d·wk−1 for 4 months. Before and after the training period, SCAT responsiveness was investigated in situ during a 60-min infusion of 1 μmol·L−1 isoproterenol and 10 μmol·L−1 ANP through microdialysis probes. Plasma metabolic parameters and physical fitness variables were measured as well. Results: Endurance training significantly increased fat-free mass and V̇O2max, while reducing plasma insulin, glucose, NEFA, low density lipoprotein (LDL)-C and the respiratory exchange ratio at rest. Training significantly lowered resting dialysate glycerol levels in SCAT. The lipid-mobilizing effect of ANP was markedly enhanced (by 191%, P < 0.05) after training as was that of isoproterenol (by 145%, P < 0.05). Resting adipose tissue blood flow as well as ANP- and isoproterenol-mediated rise in ATBF was increased after training. Conclusion: The present study shows that endurance training improves ANP- as well as β-adrenergic-receptor-mediated lipid mobilization and ATBF in the SCAT of overweight subjects. The recovery of a higher lipolytic efficiency in adipose tissue is an important benefit of a training program in overweight subjects....

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