Requirement for CB1 but not GABAB receptors in the cholecystokinin mediated inhibition of GABA release from cholecystokinin expressing basket cells

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Abstract
Non technical summary  Cholecystokinin (CCK) is a widely expressed neuropeptide known to play key roles in both normal behaviour and pathophysiological conditions. Previous reports suggested that CCK serves as a unique molecular switch that differentially regulates the output of distinct types of inhibitory interneurons in the hippocampus. The current study focused on the underlying mechanisms of the CCK actions on hippocampal interneurons, and the results show that CCK modulates transmitter release from a major class of interneurons through cannabinoid type‐1 receptor signalling mechanisms. Taken together, the present data will help us better understand how CCK modulates neuronal circuits in the brain.

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