Evolutionary history of selenocysteine incorporation from the perspective of SECIS binding proteins
Open Access
- 1 January 2009
- journal article
- Published by Springer Nature in BMC Ecology and Evolution
- Vol. 9 (1) , 229
Abstract
The co-translational incorporation of selenocysteine into nascent polypeptides by recoding the UGA stop codon occurs in all domains of life. In eukaryotes, this event requires at least three specific factors: SECIS binding protein 2 (SBP2), a specific translation elongation factor (eEFSec), selenocysteinyl tRNA, and a cis-acting selenocysteine insertion sequence (SECIS) element in selenoprotein mRNAs. While the phylogenetic relationships of selenoprotein families and the evolution of selenocysteine usage are well documented, the evolutionary history of SECIS binding proteins has not been explored.Keywords
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