Cost-utility analysis in a UK setting of self-monitoring of blood glucose in patients with type 2 diabetes
Authors:
- 23 March 2006
- journal article
- Published by Informa Healthcare in Current Medical Research and Opinion
- Vol. 22 (5) , 861-872
Abstract
Background: Self-monitoring of blood glucose (SMBG) in type 2 diabetes patients has been shown in meta-analyses of randomized trials to improve HbA1c by ∼0.4% when compared to no SMBG. However, the cost of testing supplies is high, improvements in health utility due to improved glycaemic control may be possible and cost-effectiveness has not been evaluated.Methods: A peer-reviewed validated model projected improvements in lifetime quality-adjusted life years (QALYs), long-term costs and cost-effectiveness of SMBG versus no SMBG. Markov/Monte Carlo modelling simulated the progression of complications (cardiovascular, neuropathy, renal and eye disease). Transition probabilities and HbA1c-dependent adjustments came from the United Kingdom Prospective Diabetes Study (UKPDS) and other major studies. Effects of SMBG on HbA1c came from clinical studies, meta-analyses and population studies, but can only be considered ‘moderate’ levels of evidence. Costs of complications were retrieved from published sour...Keywords
This publication has 27 references indexed in Scilit:
- Self-Monitoring of Blood Glucose in Patients With Type 2 Diabetes Who Are Not Using InsulinDiabetes Care, 2005
- Self-monitoring of blood glucose as part of a multi-component therapy among non-insulin requiring type 2 diabetes patients: a meta-analysis (1966–2004)Current Medical Research and Opinion, 2005
- Global Prevalence of DiabetesDiabetes Care, 2004
- Glycemic Control From 1988 to 2000 Among U.S. Adults Diagnosed With Type 2 DiabetesDiabetes Care, 2004
- Inside GuidelinesDiabetes Care, 2002
- Effect of Intensive Therapy on the Microvascular Complications of Type 1 Diabetes MellitusJAMA, 2002
- Evidence of an increasing prevalence of diagnosed diabetes mellitus in the Poole area from 1983 to 1996Diabetic Medicine, 1998
- Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38BMJ, 1998
- Effect of intensive therapy on the development and progression of diabetic nephropathy in the Diabetes Control and Complications TrialKidney International, 1995
- Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year studyDiabetes Research and Clinical Practice, 1995