Long-chain polyunsaturated fatty acids influence colorectal cancer progression via the interactions between the intestinal microflora and the macrophages

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Abstract
The metabolism of long-chain polyunsaturated fatty acids (LCPUFAs) is closely associated with the risk and progression of colorectal cancer (CRC). This paper aims to investigate the role of LCPUFA in the crosstalk between intestinal microflora and macrophages, as well as the effects of these three parties on the progression of CRC. The metabolism and function of LCPUFA play important roles in regulating the composition of the human gut microflora and participating in the regulation of inflammation, ultimately affecting macrophage function and polarization, which is crucial in the tumor microenvironment. The effects of LCPUFA on cellular interactions between the two species can ultimately influence the progression of CRC. In this review, we explore the molecular mechanisms and clinical applications of LCPUFA in the interactions between intestinal microflora and intestinal macrophages, as well as its significance for CRC progression. Furthermore, we reveal the role of LCPUFA in the construction of the CRC microenvironment and explore the key nodes of the interactions between intestinal flora and intestinal macrophages in the environment. It provides potential targets for the metabolic diagnosis and treatment of CRC. Graphical abstract
Funding Information
  • Graduate education innovation program project of Guangdong province (2022SFKC063, 2022XSLT047, 2022SFKC063, 2022XSLT047)
  • Natural Science Foundation of Guangdong Province (2015A030310046, 2016A030313674, 2015A030310046, 2016A030313674)
  • National Natural Science Foundation of China (81572566)
  • research foundation project of guangdong medical university (Z2015004, Z2017005)
  • Science and Technology Planning Project of Guangdong Province (2016A020215224)

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