Application of polyamide resins to polypeptide synthesis: an improved synthesis of β-endorphin using fluorenylmethoxycarbonylamino-acids

Authors:
  • EAE. Atherton
    E. Atherton
  • HFHazel Fox
    Hazel Fox
  • DHDiana Harkiss
    Diana Harkiss
  • RSR. C. Sheppard
    R. C. Sheppard
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Abstract
Use of base-labile fluorenylmethoxycarbonyl-amino-acids enables solid phase peptide synthesis of human β-endorphin to be carried out under much milder reaction conditions than formerly with improvement in product purity and yield.