HLA-DRB 1 alleles and the susceptibility of Iranian patients with breast cancer
- 1 March 2001
- journal article
- Published by Springer Nature in Pathology and Oncology Research
- Vol. 7 (1) , 39-41
Abstract
Breast cancer is considered a major malignancy among women worldwide. The contribution of genetic elements to the onset of familial breast cancer has already been established. The current study investigate the alfele frequency of HLA-DRB 1 in 36 primary operable female breast cancer patients from southern Iran by polymerase chain reaction using sequence specific primers (PCR-SSP). Results were compared with those of 36 female control subjects. Statistical analysis was performed and P values were determined for each character. Our results indicated that the frequency of HLA-DRB 1*12 allele is significantly higher in the patient group (p<0.03) compared to the control group. In addition, HLA-DRB1*11 appeared to be as the most frequent allele in the control group (29.2%) and had approximately the same distribution among the patient group (22.5%).Keywords
This publication has 17 references indexed in Scilit:
- HLA-DR and β 2 microglobulin expression in medullary and atypical medullary carcinoma of the breast: histopathologically similar but biologically distinct entitiesJournal of Clinical Pathology, 2000
- The role of CD4+ T cell responses in antitumor immunityCurrent Opinion in Immunology, 1998
- Analysis of HLA-DRB1-related alleles in Japanese patients with lung cancer - relationship to genetic susceptibility and resistance to lung cancerJournal of Cancer Research and Clinical Oncology, 1998
- Class II-Transfected Tumor Cells Directly Present Endogenous Antigen to CD4+ T Cells In Vitro and Are APCs for Tumor-Encoded Antigens In VivoJournal of Immunotherapy, 1998
- Serological and molecular study on the HLA phenotype of female breast cancer patientsEuropean Journal of Cancer, 1994
- A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1Science, 1994
- Changing trends: An overview of breast cancer incidence and mortalityCancer, 1994
- HLA‐DR typing by PCR amplification with sequence‐specific primers (PCR‐SSP) in 2 hours: An alternative to serological DR typing in clinical practice including donor‐recipient matching in cadaveric transplantationTissue Antigens, 1992
- A simple salting out procedure for extracting DNA from human nucleated cellsNucleic Acids Research, 1988
- The isolation of high molecular weight DNA from whole organisms or large tissue massesAnalytical Biochemistry, 1978