MicroRNAs delivered by extracellular vesicles: an emerging resistance mechanism for breast cancer
- 22 November 2013
- journal article
- review article
- Published by Springer Nature in Tumor Biology
- Vol. 35 (4) , 2883-2892
Abstract
Resistance to chemotherapy and endocrine therapy as well as targeted drugs is a major problem in treatment of breast cancer. Over the last decades, emerging studies have revealed that extracellular vesicles, which are chronically released by breast cancer cells and surrounding stromal cells, influence the action of most commonly used therapeutics. Such modulatory effects have been related to the transport of biologically active molecules including proteins and functional microRNAs. In this review, we highlight recent studies regarding extracellular vesicle-mediated microRNA delivery in formatting drug resistance. We also suggest the use of extracellular vesicles as a promising method in antiresistance treatment.Keywords
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