Real-Time Zeta Potential Analysis of Microchannel Surfaces during Aminosilane Deposition and Exposure Using Current Monitoring
- 1 December 2021
- journal article
- research article
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 93 (49) , 16512-16519
Abstract
Surface coatings are extensively used in capillary electrophoresis to increase separation efficiency and resolution. The stability of these coatings across a wide pH range is desirable to achieve repeatable migration times; therefore, a comprehensive understanding of coating degradation timescales is needed. We present a novel platform for automated zeta potential analysis based upon current monitoring that delivers improved time resolution over the existing methods. Using our platform, we measure the zeta potential continuously during aminosilane coating reactions and infer changes in the surface composition. We found that the change in the zeta potential after coating depended on the monomer type and solvent, while its stability was influenced by the coating solvent and exposure pH. Our versatile platform provides an elegant approach for evaluating the molecular composition, reactivity, and stability of surfaces in real time.Keywords
Funding Information
- American Diabetes Association (1-17-VSN-18)
- Leona M. and Harry B. Helmsley Charitable Trust (2019PG-T1D022)
This publication has 48 references indexed in Scilit:
- How To Prepare Reproducible, Homogeneous, and Hydrolytically Stable Aminosilane-Derived Layers on SilicaLangmuir, 2011
- Roles of solution conductivity mismatch in transient current and fluid transport in electrolyte displacement by electro-osmotic flowMicrofluidics and Nanofluidics, 2010
- A Y-channel design for improving zeta potential and surface conductivity measurements using the current monitoring methodMicrofluidics and Nanofluidics, 2008
- Kinetics of hydrolysis and self condensation reactions of silanes by NMR spectroscopyColloids and Surfaces A: Physicochemical and Engineering Aspects, 2008
- Electrokinetics after SmoluchowskiColloids and Surfaces A: Physicochemical and Engineering Aspects, 2003
- Rate of Access to the Binding Sites in Organically Modified Silicates. 1. Amorphous Silica Gels Grafted with Amine or Thiol GroupsChemistry of Materials, 2002
- Formation of Uniform Aminosilane Thin Layers: An Imine Formation To Measure Relative Surface Density of the Amine GroupLangmuir, 1996
- Factors contributing to the stability of alkoxysilanes in aqueous solutionJournal of Adhesion Science and Technology, 1992
- Electrophoresis in fused-silica capillaries: the influence of organic solvents on the electroosmotic velocity and the .zeta. potentialAnalytical Chemistry, 1991
- Tracer study of kinetics and mechanism of hydrolytically induced interfacial failureJournal of Polymer Science Part C: Polymer Symposia, 1971