Managed Problem Solving for Antiretroviral Therapy Adherence

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Abstract
Adherence to pharmacotherapy is key to preventing progression of treatable chronic diseases. Unfortunately, clinically significant nonadherence is common in diabetes mellitus,1 hypertension,2 hypercholesterolemia,3 and human immunodeficiency virus (HIV),4 for example. Adherence barriers include depression,5 substance abuse,6 regimen complexity,7 poor social support,8 and low health literacy,9,10 among others. Adherence interventions have had limited effects, which often wane over subsequent months.11-13

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