Effects of Honey Against the Accumulation of Adipose Tissue and the Increased Blood Pressure on Carbohydrate-Induced Obesity in Rat

Authors:
  • SRSamanta Romero-Silva
    Samanta Romero-Silva
  • MRMiguel Angel Martinez R
    Miguel Angel Martinez R
  • LRLaura P. Romero-Romero
    Laura P. Romero-Romero
  • OROralia Rodriguez
    Oralia Rodriguez
  • CGC. Gerardo Salas G
    C. Gerardo Salas G
  • NMNicole Morel
    Nicole Morel
  • FLFrancisco Javier Lopez-Munoz
    Francisco Javier Lopez-Munoz
  • LLLuis Angel Lima-Mendoza
    Luis Angel Lima-Mendoza
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Abstract
This study was designed to assess the effect of honey supplementation and sugar-based hypercaloric regimen on weight gain and blood pressure (BP) in Wistar rats. Animals were fed for 8 weeks with standard diet (S-free) or a hypercaloric diet (standard chow and 30% sugar in drinking water), (SF), or standard chow supplemented with fat and honey and 10% sugar in drinking water (HF). Overall weight gain and body fat levels were significantly higher in SF and HF than in S-free. Fat cells were significantly larger in SF compared with HF. Compared with SF and S-free, HF had higher glucose, but triglycerides, and LDLc levels were not different. BP was significantly higher in SF but not in HF compared to S-free. These observations indicate that honey may afford a protection against increase in BP and in fat cell size resulting from a hypercaloric diet.