Cohesin in cancer: chromosome segregation and beyond
Author:
- 23 May 2014
- journal article
- review article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 14 (6) , 389-393
Abstract
Cohesin is an evolutionarily conserved, four-subunit complex that entraps DNA fibres within its ring-shaped structure. It was originally identified and named for its role in mediating sister chromatid cohesion, which is essential for chromosome segregation and DNA repair. Increasing evidence indicates that cohesin participates in other processes that involve DNA looping, most importantly, transcriptional regulation. Mutations in genes encoding cohesin subunits and other regulators of the complex have recently been identified in several types of tumours. Whether aneuploidy that results from chromosome missegregation is the major contribution of cohesin mutations to cancer progression is under debate.Keywords
This publication has 45 references indexed in Scilit:
- Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cellsProceedings of the National Academy of Sciences, 2013
- Frequent inactivating mutations of STAG2 in bladder cancer are associated with low tumour grade and stage and inversely related to chromosomal copy number changesHuman Molecular Genetics, 2013
- Aurora B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating SororinProceedings of the National Academy of Sciences, 2013
- Replication stress links structural and numerical cancer chromosomal instabilityNature, 2013
- Phosphorylation-enabled binding of SGO1–PP2A to cohesin protects sororin and centromeric cohesion during mitosisNature Cell Biology, 2012
- HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycleNature, 2012
- Systematic Reduction of Cohesin Differentially Affects Chromosome Segregation, Condensation, and DNA RepairCurrent Biology, 2010
- Human mutation rate associated with DNA replication timingNature Genetics, 2009
- CTCF physically links cohesin to chromatinProceedings of the National Academy of Sciences, 2008
- Chromatid cohesion defects may underlie chromosome instability in human colorectal cancersProceedings of the National Academy of Sciences, 2008