Clinical characteristics and surgical results in hyperparathyroidism caused by water‐clear cell hyperplasia

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Abstract
Twenty‐nine patients were treated for water‐clear cell hyperplasia (WCCH) of the parathyroid glands and 531 for single adenoma during a 26‐year period ending in 1978. The annual incidence of WCCH did not change during the period, whereas the number of adenoma cases markedly increased. Patients with WCCH had higher serium calcium levels and more severe disease than did those with adenoma. Mental symptoms and impaired renal function were especially common, and 4 patients later died of renal failure. The reversed sex ratio, with more men than women among the WCCH patients, can explain their higher prevalence of renal calculi. Operative treatment resulted in a cure of hyperparathyroidism (HPT) in 24 WCCH patients, 7 of whom developed hypocalcemia. Five patients remained hypercalcémie. Because of the morbidity of WCCH, persistent HPT should be avoided and more radical surgery performed than is currently recommended.
Funding Information
  • Medicinska Forskningsrådet (B 78-12X04757-03)

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