Contrasting molecular patterns of mhc class ii alleles associated with the anti‐sm and anti‐rnp precipitin autoantibodies in systemic lupus erythematosus

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Abstract
Objective. To find evidence of a potential genetic predisposition to the anti‐Sm or anti‐RNP precipitin autoantibody responses.Methods. HLA–DR and DQ alleles determined by restriction fragment length polymorphism and/or oligo‐typing in 49 subjects with either anti‐Sm alone or anti‐RNP alone were compared with those in 139 race‐matched normal control subjects and 59 race‐matched lupus patients without anti‐Sm and anti‐RNP auto‐antibodies.Results. Black patients with anti‐Sm precipitin had increased frequencies of HLA‐DR2 and the DQw6‐associated DQA1*0102 (P = 0.007, odds ratio [OR] = 6.7) and DQB1*0602 (P = 0.001, OR = 9.1) chain alleles compared with normal black control subjects. Black patients with anti‐RNP precipitin showed significant increases in the DQw5‐associated DQA1*0101 (P = 0.03, OR = 5.5) and DQB1*0501 (P = 0.002, OR = 23.3) chain alleles compared with lupus patients without anti‐Sm or RNP. White patients with anti‐RNP precipitin showed an increased frequency of the DQw8‐associated allele DQB1*0302 (P = 0.02, OR = 3.7) compared with normal controls, as well as an increased frequency of the DQw5‐associated alleles DQA1*0101 and DQB1*0501 (P = 0.05, OR = 4.2) compared with lupus patients without anti‐Sm or RNP. There were no specific HLA–DR2 or DR4 subtype associations found with either anti‐Sm or RNP precipitin autoantibodies.Conclusion. There are distinct patterns of major histocompatibility complex class II allele associations with the anti‐Sm versus the anti‐RNP precipitin autoantibody responses, and HLA–DQ associations may be more primary than HLA–DR associations.

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