Coaxial Electrohydrodynamic Atomization for the Production of Drug-Loaded Micro/Nanoparticles
Open Access
- 14 February 2019
- journal article
- review article
- Published by MDPI AG in Micromachines
- Vol. 10 (2) , 125
Abstract
Coaxial electrohydrodynamic atomization (CEHDA) presents a promising technology for preparing drug-loaded micro/nanoparticles with core-shell structures. Recently, CEHDA has attracted tremendous attention based on its specific advantages, including precise control over particle size and size distribution, reduced initial burst release and mild preparation conditions. Moreover, with different needles, CEHDA can produce a variety of drug-loaded micro/nanoparticles for drug delivery systems. In this review, we summarize recent advances in using double-layer structure, multilayer structure and multicomponent encapsulation strategies for developing micro/nanoparticles. The merits of applying multiplexed electrospray sources for high-throughput production are also highlighted.Keywords
Funding Information
- National Natural Science Foundation of China (81202378, 81311140268, 81803495)
- China Postdoctoral Science Foundation (2018M643016)
This publication has 101 references indexed in Scilit:
- Preparation of multicompartment sub-micron particles using a triple-needle electrohydrodynamic deviceJournal of Colloid and Interface Science, 2013
- Design, Fabrication, and Characterization of Linear Multiplexed Electrospray Atomizers Micro-Machined from Metal and PolymersAerosol Science and Technology, 2013
- Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery CarrierPolymers, 2011
- Compact polymer multi-nozzles electrospray device with integrated microfluidic feeding systemJournal of Electrostatics, 2011
- Recent Progress in Nano‐biotechnology: Compartmentalized Micro‐ and Nanoparticles via Electrohydrodynamic Co‐jettingSmall, 2011
- Core/shell microspheres via coaxial electrohydrodynamic atomization for sequential and parallel release of drugsJournal of Biomedical Materials Research Part A, 2010
- One-step electrohydrodynamic production of drug-loaded micro- and nanoparticlesJournal of The Royal Society Interface, 2009
- Electrohydrodynamics: A facile technique to fabricate drug delivery systemsAdvanced Drug Delivery Reviews, 2009
- Fabrication of Elastin-Like Polypeptide Nanoparticles for Drug Delivery by ElectrosprayingBiomacromolecules, 2008
- Generation of multilayered structures for biomedical applications using a novel tri-needle coaxial device and electrohydrodynamic flowJournal of The Royal Society Interface, 2008