Genetic Diversity of the Polyomavirus JC and Implications for the Pathogenesis of Progressive Multifocal Leukoencephalopathy
Open Access
Abstract
JC Polyomavirus (JCPyV) is a non-enveloped virus with circular double stranded DNA responsible for the rare but fatal demyelinating disease known as progressive multifocal leukoencephalopathy (PML). In its host, this virus exists in two different forms: one found in the periphery, named archetype, and another found in the central nervous system, named prototype. This form usually harbors recombinations in the non-coding control region (NCCR), a key region that contains sequences regulating viral replication and containing binding sites for cellular transcription factors. This form also contains mutations in the capsid protein, especially VP1. Due to the diversity of the JCPyV, a natural polymorphism also exists between the different genotypes. In this review, we aimed to summarize the main features of the archetype and prototype strains in order to facilitate the interpretation of sequence data that are increasingly generated by new sequencing technologies. This will also help to distinguish mutations associated with the natural polymorphism from those specific to the prototype form.Keywords
This publication has 75 references indexed in Scilit:
- JC Virus–Related RetinopathyJAMA Ophthalmology, 2025
- Recent changes to virus taxonomy ratified by the International Committee on Taxonomy of Viruses (2022)Archives of Virology, 2022
- Fatal encephalopathy with wild‐type JC virus and ruxolitinib therapyAnnals of Neurology, 2019
- Detection of JC virus archetype in cerebrospinal fluid in a MS patient with dimethylfumarate treatment without lymphopenia or signs of PMLJournal of Neurology, 2018
- Heterogeneous imaging characteristics of JC virus granule cell neuronopathy (GCN): a case series and review of the literatureJournal of Neurology, 2014
- Sequential changes in the non-coding control region sequences of JC polyomaviruses from the cerebrospinal fluid of patients with progressive multifocal leukoencephalopathyArchives of Virology, 2012
- Fulminant JC virus encephalopathy with productive infection of cortical pyramidal neuronsAnnals of Neurology, 2009
- JC virus granule cell neuronopathy: A novel clinical syndrome distinct from progressive multifocal leukoencephalopathyAnnals of Neurology, 2005
- Lack of disease-specific amino acid changes in the viral proteins of JC virus isolates from the brain with progressive multifocal leukoencephalopathy.Archives of Virology, 2000
- Propagation of the Human Polyomavirus, JCV, in Human Neuroblastoma Cell LinesVirology, 1997