1-Hour Venous Plasma Glucose and Incident Prediabetes and Diabetes in Asian Indians

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Abstract
Background: This study evaluated 1-h plasma glucose (1HrPG) levels during an oral glucose tolerance test (OGTT) in predicting progression to diabetes and prediabetes among individuals with normal glucose tolerance (NGT). Subjects and Methods: After analyzing the electronic records of 32,809 subjects who had undergone an OGTT, we identified 1,179 subjects who had NGT at baseline, defined as fasting plasma glucose (FPG) of Results: On follow-up, 148 (12.6%) subjects developed diabetes, and 392 (33.2%) developed prediabetes. In those with 1HrPG values ≥155 mg/dL, 19.5% converted to diabetes compared with 10% among those with 1HrPG of ≥143 to Conclusions: Among NGT subjects with elevated 1HrPG values during an OGTT, progression to diabetes and prediabetes is greater, and the rate of progression is also faster.

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