Occult Breast Cancer Presenting as Sternum Pain

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Abstract
Bone metastasis has been reported in up to 70% of patients with advanced breast cancer. A total of 55.76% of skeletal metastases in women were derived from breast cancer. However, patients with bone metastasis from an occult primary breast cancer are a rare subset of patients. Here, we present the case of a 38-year-old woman who had sternum pain for 4 months. A whole-body PET-CT scan revealed that the FDG uptake of both the sternum and internal mammary node was significantly increased. The final diagnosis of occult breast cancer was established by immunohistochemical (IHC) staining, which is of great significance for identifying the origin of a metastatic tumor despite no visualized lesions of mammary glands.
Funding Information
  • National Natural Science Foundation of China (82073142, 82173089, 82073332, Z-2017-24-2108)
  • Immunoradiotherapy Research Fund of Chinese Society of Radiation Oncology (82073142, 82173089, 82073332, Z-2017-24-2108)