The spatiotemporal distribution of Foxi1-expressing pulmonary ionocytes in the mouse airways

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Abstract
This study provides the first spatiotemporal map of Foxi1 + pulmonary ionocytes in mouse airways. These rare cells, which express the majority of CFTR mRNA, emerge postnatally near developing submucosal glands and concentrate in the laryngeal subglottis during adulthood. Their distribution remains unaltered in Cftr ΔF508/ΔF508 mice, suggesting CFTR dysfunction does not disrupt ionocyte patterning.
Funding Information
  • Fondo Nacional de Desarrollo Científico y Tecnológico (3220672)
  • Fondo Nacional de Desarrollo Científico y Tecnológico (1221257)
  • Swedish Association for Cystic Fibrosis Research Founcation
  • Erica Lederhausens Minnesstiftelse
  • Cystic Fibrosis Trust (DA004)
  • ANID Anillo de Tecnologia NanoAir (ACT250073)
  • Southern Bioimaging Platform (SBIP)-USS (FONDEQUIP-EQY240004)

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