Manganese-Catalyzed α-Alkylation of Ketones, Esters, and Amides Using Alcohols
Authors:
Open Access
- 2 October 2018
- journal article
- research article
- Published by American Chemical Society (ACS) in ACS Catalysis
- Vol. 8 (11) , 10300-10305
Abstract
Herein we report the manganese catalyzed C-C bond forming reactions via α-alkylation of ketones, amides and esters, using primary al-cohols. β-alkylation of secondary alcohols by primary alcohols to obtain α-alkylated ketones is also reported. The reactions are catalyzed by a (iPr-PNP)Mn(H)(CO)2 pincer complex under mild conditions in the presence of (catalytic) base liberating water (and H2 in the case of secondary alcohol alkylation) as the sole-byproduct.Keywords
Funding Information
- Israel Science Foundation
- H2020 European Research Council (692775)
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