Development of a radioimmunoassay for pregnancy‐specific beta1‐globulin and its measurement in serum of patients with trophoblastic and non‐trophoblastic tumours

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Abstract
Levels of human pregnancy‐specific or trophoblast‐specific beta1‐globulin (TBG) were measured by double‐antibody radioimmunoassay (RIA) in 103 patients with trophoblastic tumours and in 114 patients with a variety of non‐trophoblastic tumours. The sensitivity of RIA for TBG was about 1 ng per ml. Twenty healthy adult females and males had levels below 1 ng per ml. Using the RIA for measurement of TBG in sera which were selected from immunodiffusion‐TBG‐negative samples, we detected elevated TBG levels in 76.7% of cases with trophoblastic tumours and in 15% of different cases with non‐trophoblastic malignancies. The diagnostic and prognostic significance of the measurement of TBG levels by RIA in patients with trophoblastic tumours is discussed.

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