Base-promoted deacylation of 2-acetyl-2,5-dihydrothiophenes and their oxygen-mediated hydroxylation
Open Access
- 28 January 2026
- journal article
- Published by Beilstein Institut in Beilstein Journal of Organic Chemistry
- Vol. 22, 192-204
Abstract
Solvent-dependent transformations of polysubstituted 2-acetyl-2,5-dihydrothiophenes to the corresponding 2-hydroxy- or deacetylated derivatives are described. The treatment of a methanolic solution of the dihydrothiophene substrates with sodium methoxide afforded the deacylated products. Conversely, the treatment with sodium ethoxide in an oxygen saturated ethanolic solution produced 2-hydroxy substituted 2,5-dihydrothiophenes.Keywords
Funding Information
- Russian Science Foundation (23-13-00248)
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