Nanomaterials in tuberculosis DNA vaccine delivery: historical perspective and current landscape

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Abstract
Vaccinations, especially DNA vaccines that promote host immunity, are the most effective interventions for tuberculosis (TB) control. However, the vaccine delivery system exhibits a significant impact on the protective effects of the vaccine. Recently, effective nanomaterial-based delivery systems (including nanoparticles, nanogold, nanoliposomes, virus-like particles, and virus carriers) have been developed for DNA vaccines to control TB. This review highlights the historical development of various nanomaterial-based delivery systems for TB DNA vaccines, along with the emerging technologies. Nanomaterial-based vaccine delivery systems could enhance the efficacy of TB vaccination; therefore, this summary could guide nanomaterial selection for optimal and safe vaccine delivery, facilitating the design and development of highly effective TB vaccines.
Funding Information
  • Natural Science Foundation of Hainan Province (2019JJ40321)
  • Scientific Research Project of Hunan Provincial Health Commission (20201933)
  • National Natural Science Foundation of China (32000651)
  • National Natural Science Foundation of China (31670938)
  • National Natural Science Foundation of China (32070924)
  • Natural Science Foundation Project Program of Chongqing (2019jcyjA-msxmx0159)
  • Natural Science Foundation Project Program of Chongqing (2014jcyjA0107)

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