Paramagnetic metalloporphyrins as potential contrast agents in NMR imaging
Authors:
- Chi-Wan ChenCCChi-Wan Chen
- Jack S. CohenJCJack S. Cohen
- Charles E. MyersCMCharles E. Myers
- Miriam SohnMSMiriam Sohn
- 12 March 1984
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 168 (1) , 70-74
Abstract
Several water‐soluble paramagnetic metalloporphyrins were found to increase significantly the relaxation rate (1/T 1) of water. Such compounds are known to be selectively retained by tumors in animals, and consequently we identify them as potential contrast agents for tumors in NMR imaging.Keywords
This publication has 7 references indexed in Scilit:
- Work in progress: potential oral and intravenous paramagnetic NMR contrast agents.Radiology, 1983
- Work in progress: methods of contrast enhancement for NMR imaging and potential applications. A subject review.Radiology, 1983
- Preparation of 109Pd-hematoporphyrin for selective lymphatic ablation using N-methylhematoporphyrinThe International Journal of Applied Radiation and Isotopes, 1981
- Synthetic porphyrins as tumour-localizing agentsBritish Journal of Radiology, 1981
- The distribution of various water soluble radioactive metalloporphyrins in tumor bearing miceBioinorganic Chemistry, 1975
- Nuclear magnetic resonance studies of metal porpyrins. I. Kinetics of ligand exchange and of transitions between high- and low-spin states in the systen hemin-pyridine-waterJournal of the American Chemical Society, 1971
- Relaxation Effects in Nuclear Magnetic Resonance AbsorptionPhysical Review B, 1948