Low HDL Cholesterol Is a Risk Factor for Deficit and Decline in Memory in Midlife

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Abstract
Objective— The purpose of this study was to examine the relationship between fasting serum lipids and short-term verbal memory in middle-aged adults. Methods and Results— Total cholesterol, high-density lipoprotein cholesterol (HDL-C), triglycerides, and memory were measured twice, at mean ages 55 and 61, in 3673 male and female participants of the Whitehall II study. Short-term verbal memory was assessed using a 20-word list. Logistic regression was used to model associations between ATP-III categories of lipids and memory deficit (recall of ≤4 words) and decline (decrease of ≥2 words). Analyses were adjusted for education, occupational position, coronary heart disease, stroke, hypertension, use of medication, diabetes, smoking, and alcohol consumption. Compared to high HDL-C (≥60 mg/dL), low HDL-C ( Conclusions— HDL-C levels are potentially modifiable, and our results suggest that low HDL-C is associated with poor memory and decline in memory in middle-aged adults.

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