Chiral Amino-Amides as Solution Phase and Immobilized Ligands for the Catalytic Asymmetric Alkylation of Aromatic Aldehydes

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Abstract
Novel chiral amino-amide 9-keto-bispidines are investigated as ligands in the addition reaction of diethylzinc to aromatic aldehydes. The ligands are easily obtained by a single step procedure starting from commercially available products. Selected ligands were also supported onto different insoluble resins in order to test their activity as heterogeneous catalysts.