Genetic and Phenotypic Correlates of Colorectal Cancer in Young Patients
Authors:
- Rajiv V. DattaRDRajiv V. Datta
- Michael P. LaQuagliaMLMichael P. LaQuaglia
- Philip B. PatyPPPhilip B. Paty
- 13 January 2000
- journal article
- letter
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 342 (2) , 137-138
Abstract
Colorectal cancer in young patients (age, 21 years or younger) is rare and has a well-recognized aggressive, often fatal course, but the genetic origin and developmental biology of this disease are poorly understood.1 We analyzed data from Memorial Sloan-Kettering Cancer Center on young patients with colorectal cancer to assess the hereditary basis of this disease. We used pedigree analysis and molecular assessment to identify microsatellite instability and other genetic markers. Microsatellite instability is a characteristic pattern of genetic instability seen in microsatellite DNA that occurs in most hereditary nonpolyposis colorectal cancers (more than 95 percent).2Keywords
This publication has 3 references indexed in Scilit:
- Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patientsNature Medicine, 1996
- Genetic instability occurs in the majority of young patients with colorectal cancerNature Medicine, 1995
- Prognostic factors and outcome in patients 21 years and under with colorectal carcinomaJournal of Pediatric Surgery, 1992