Effect of some antiparkinsonian drugs on catecholamine neurons

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Abstract
The inhibitory effect of some antiparkinsonian drugs on the accumulation of catecholamines into rat dopamine and noradrenaline neurons was studied with isotope and histochemical fluorescence methods in vivo and in vitro. Benztropine was the most potent drug hitherto tested to inhibit accumulation of catecholamines into dopamine neurons and was effective down to a dose of 10mg/kg. Also ethybenztropine, brompheniramine, diphenylpyraline, chlorpheniramine and methixene, in doses of 50 mg/kg, inhibited accumulation of catecholamines. Atropine, scopolamine, benzhexol, diphenhydramine and many other antiparkinsonian agents were ineffective.

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