Gastric antisecretory, antiulcer and cytoprotective properties of ethanolic extract of Alpinia galanga willd in rats

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Abstract
The effect of Alpinia galanga extract has been studied on experimentally induced gastric ulcers in rats. The ethanolic extract of A. galanga at a dose of 500 mg/kg, significantly reduced the intensity of gastric mucosal damage induced by pyloric ligation and hypothermic restraint stress in rats. It produced a significant decrease in gastric secretion in pylorus ligated rats and a highly significant cytoprotective effect against 80% ethanol‐, 0.6 M HCI‐, 0.2 M NaOH‐ and 25% NaCl‐induced cytodestruction. Pretreatment with the extract significantly prevented hypothermic stress‐induced gastric wall mucus depletion. These findings suggest that a significant antisecretory and cytoprotective action of A. galanga may be responsible for its antiulcer activity.

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